Les logiciels d'analyse statistique

Conception de séries chronologiques

Contenu

Titre (dcterms:title)

fr Conception de séries chronologiques
en Time series design

Identifiant (dcterms:identifier)

label (rdfs:label)

en Time series design
fr Conception de séries chronologiques

editor preferred label (obo:IAO_0000111)

en Time series design

example of usage (obo:IAO_0000112)

en PMID: 14744830-Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, agricultural and pharmaceutical sciences. There are myriad sources of uncertainty in microarray experiments, and rigorous experimental design is essential for fully realizing the potential of these valuable resources. Two questions frequently asked by biologists on the brink of conducting cDNA or two-colour, spotted microarray experiments are 'Which mRNA samples should be competitively hybridized together on the same slide?' and 'How many times should each slide be replicated?' Early experience has shown that whilst the field of classical experimental design has much to offer this emerging multi-disciplinary area, new approaches which accommodate features specific to the microarray context are needed. In this paper, we propose optimal designs for factorial and time course experiments, which are special designs arising quite frequently in microarray experimentation. Our criterion for optimality is statistical efficiency based on a new notion of admissible designs; our approach enables efficient designs to be selected subject to the information available on the effects of most interest to biologists, the number of arrays available for the experiment, and other resource or practical constraints, including limitations on the amount of mRNA probe. We show that our designs are superior to both the popular reference designs, which are highly inefficient, and to designs incorporating all possible direct pairwise comparisons. Moreover, our proposed designs represent a substantial practical improvement over classical experimental designs which work in terms of standard interactions and main effects. The latter do not provide a basis for meaningful inference on the effects of most interest to biologists, nor make the most efficient use of valuable and limited resources.

has curation status (obo:IAO_0000114)

definition (obo:IAO_0000115)

en Groups of assays that are related as part of a time series.
fr Groupes d'essais liés à une série chronologique.

editor note (obo:IAO_0000116)

PRS-AGB adding formal restriction on independent variable specification about time (march 2013) and making time series design class a defined class.

term editor (obo:IAO_0000117)

en Philippe Rocca-Serra on behalf of MO
fr Jean-Marc Meunier

definition source (obo:IAO_0000119)

en MO_887

imported from (obo:IAO_0000412)

subClassOf (rdfs:subClassOf)

hierarchy level (md:hierarchyLevel)

fr 1
fr 2
fr 3
fr 4
fr 5
fr 6
fr 7
fr 8
fr 9

has narrower (skos:narrower)

Ressources liées

Filtre par propriété

Descripteur statistique
Titre Label alternatif Classe
Inner Diameter of Landing Gear Triunion Fiche concept statistique Dataset
90 Day Bank Bills Fiche concept statistique Dataset
Magnitudes of Variable Star Fiche concept statistique Dataset
Voice Data from Singing the Vowel 'ooh' Fiche concept statistique Dataset
Pressure Difference between Easter Island and Darwin Fiche concept statistique Dataset
Magnitudes of Variable Star Cepheid 1 Fiche concept statistique Dataset
Magnitudes of Variable Star Cepheid 2 Fiche concept statistique Dataset
Magnitudes of Eclipsing Binary Variable Star Fiche concept statistique Dataset
Magnitudes of Variable Star RR Lyrae 1061 Fiche concept statistique Dataset
Magnitudes of Variable Star RR Lyrae 1198 Fiche concept statistique Dataset
Magnitudes of Variable Star RR Lyrae 1263 Fiche concept statistique Dataset
Activity of Fiddler Crabs Fiche concept statistique Dataset
Forces on a Cylinder Suspended in Water Fiche concept statistique Dataset
Circadian Rhythms in the Long-Tail Pocket Mouse Fiche concept statistique Dataset
Circadian Rhythms in the Prairie Deer Mouse Fiche concept statistique Dataset
Rhythms in the Long-Tail Pocket Mouse (with 24.5 hour days) Fiche concept statistique Dataset
Pigs Slaughtered in Victoria Fiche concept statistique Dataset
Melbourne Daily Rainfall Fiche concept statistique Dataset
Melbourne Temperatures Fiche concept statistique Dataset
Adelaide Rainfall Fiche concept statistique Dataset
Brisbane Temperatures Fiche concept statistique Dataset
Hotels, Motels and Guesthouses in Victoria Fiche concept statistique Dataset
CPI for Five Countries Fiche concept statistique Dataset
Brisbane Consumer Price Indices Fiche concept statistique Dataset
House Price Indexes Fiche concept statistique Dataset

Annotations

There are no annotations for this resource.